Number in Neuroscience

1 min read

This is some numbers I collected long time ago.

What How Much Where
Constants and Equations (a list)

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Brain Facts (a list)

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Metabolic Energy (a list)

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Number of neurons and synapses
neurons 1011
synapses 1014
pyramidal neurons >80% Attwell and Laughlin 2001
glutamate synapses >90% Attwell and Laughlin 2001
ganglion cells in human regina 1.5 million de Gelder, et al, Out of Mind, chapter 1
ganglion cells in human regina projected to LGN 90% of 1.5M de Gelder, et al, Out of Mind, chapter 1
ganglion cells in human regina projected to superior colliculus 105 de Gelder, et al, Out of Mind, chapter 1
Energy
Energy of one ATP molecule 25kT

ref
Energy of 1 mol ATP molecules (at
normal cellular condition, ATP = 10mM, ADP = 0.1mM, Pi = 10mM)
53327 J
20kT
homework in integrative neuroscience I,
by Paul Pfaffinger
Energy taken up by male adult per day 10^7 J

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original ref
% Oxygen consumption of brain to total 20%

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% energy consumed to pumps Na and K, to
total brain energy usage
50%

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ATP concentration at normal cellular
conditions
10 mM homework in integrative neuroscience I,
by Paul Pfaffinger
ADP 0.1 mM
Pi 10 mM
Phosphate bond energy at Standard
Condition
7.3kcal/mol
30.5kJ/mol
5.1*10^(-20)J/bond
11.8 kT


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Number
# of calcium ions flow into cell during an AP 200-13000/active zone/spike Borst and Sakmann, 1996
# of neurotransmitter in a vesicle 4000 Kandel
# of vesicles in presynaptic bouton 1-10 CNS
diameter of a vesicle 50nm and 70-200nm
PH w/i a vesicle 5.5
PH cytoplasm 7
# of vesicle released per synaptic
transmission
1 Levy and Baxter 2002
# of ions transported by a single
acetylcholine-activated channel in one second
10^7
# of ions transported by Na/K pump per
second
10^3
Information
information rate of fully light-adapted
photo-receptor cell under random stimuli
1000 bit/s

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information rate of LMC 1600 bit/s

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synapse between photo-receptor and LMC 55 bit/s

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energy per bit of photo-receptor 7*10^6 ATP/bit

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energy per bit of LMC 0.9-3*10^6 ATP/bit

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energy per bit of chemical synapse 2-6*10^4 ATP/bit

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Other
Biological Membrane Capacitance 1uF/cm2

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Number of Neurons in brain 10^11
Number of Synapses in cerebral cortex 60-240trillion Brain facts
probability to release a vesicle if
action potential arrives presynaptically
0.1-0.5

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Laughlin and Sejnowski, 2003



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