第十四期 fNIRS Journal Club 通知 2020/11/29,11am

1 min read

窦皓然

北京时间2020年11月29日周日上午11点, 四川师范大学和芬兰University of Jyväskylä联合培养博士生窦皓然将为大家讲解他们最近发布在NeuroImage上关于社会排斥的文章。欢迎大家参加并参与讨论。

时间: 北京时间2020年11月29日周日上午11点
地点: https://zoom.com
房间号: 838 4895 7455
密码: 802777

Dou, Lei, Cheng, Wang, Leppänen (2020) Social exclusion influences conditioned fear acquisition and generalization: A mediating effect from the medial prefrontal cortex NeuroImage 218, 116735

Abstract
Fear acquisition and generalization play key roles in promoting the survival of mammals and contribute to anxiety disorders. While previous research has provided much evidence for the repercussions of social exclusion on mental health, how social exclusion affects fear acquisition and generalization has received scant attention. In our study, participants were divided into two groups according to two Cyberball paradigm conditions (exclusion/inclusion). Both groups underwent a Pavlovian conditioning paradigm, functional near-infrared spectroscopy (fNIRS), and skin conductance response (SCR) assessments. We aimed to determine the effects of social exclusion on fear acquisition and generalization and whether modulation of the medial prefrontal cortex (mPFC) mediates this relationship. Our results showed that socially excluded participants featured significantly higher and lower shock risk scores to safety stimuli (conditioned stimulus, CS-) and threatening stimuli (CS+), respectively, than did socially included subjects during fear acquisition. The exclusion group had increased skin conductance responses (SCRs) to CS and exhibited heightened shock risk and increased SCRs to generalized stimuli compared with the inclusion group. The fNIRS results demonstrated that the CS ​+ ​evoked larger oxy-Hb changes in the mPFC in the inclusion group than in the exclusion group during fear acquisition. Furthermore, the oxy-Hb of left mPFC of CS ​+ ​mediated the effect on the association between social exclusion and perceived risk of CS+ in the fear acquisition. Our results indicate that social exclusion impairs fear acquisition and generalization via the mediation of the mPFC and that social exclusion increases susceptibility to anxiety disorders through bias processing of fear discrimination in fear acquisition and generalization. By studying the role of social relationship in fear acquisition and generalization, our research provides new insights into the pathological mechanisms of anxiety disorder. Copyright © 2020. Published by Elsevier Inc.

第十八期 fNIRS Journal Club 通知 2021/04/25,10am

北京师范大学的朱朝喆教授将为大家讲解他们最近几年在经颅脑图谱(Transcranial brain Atlas) 方面做的工作。热烈欢迎大家参与讨论。 时间: 北京时间2021年4月25日周日上午10点地点: https://zoom.com房间号: 863 1929 4069密码: 113560 朱朝喆教授简介:北京师范大学教授、博士生导师;认知神经科学与学习国家重点实验室,脑成像与神经调控实验室负责人(PI), 主要从事 fNIRS 脑成像与 TMS 神经调控相关理论研究与新技术开发。主持国家自然科学基金委重点项目、科技部重大仪器专项课题等。在 Science Advances,Brain 等期刊发表 SCI 论文八十余篇,SCI 引用 11851...
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第十七期 fNIRS Journal Club 视频

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第十七期 fNIRS Journal Club 通知 2021/03/27,10am

北京师范大学的卢春明教授将为大家讲解他们最近发布的一篇用超扫描研究恋爱关系的文章。热烈欢迎大家参与讨论。 时间: 北京时间2021年3月27日周六上午10点地点: https://zoom.com房间号: 870 6817 2529 密码: 433527 Long, Zheng, Zhao, Zhou, Zhai, Lu (2020) Interpersonal Neural Synchronization during Interpersonal Touch Underlies Affiliative...
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